Assuntos
Antineoplásicos/uso terapêutico , Indóis/uso terapêutico , Melanoma/secundário , Terapia de Alvo Molecular , Mutação , Proteínas Proto-Oncogênicas B-raf/antagonistas & inibidores , Neoplasias Cutâneas/patologia , Sulfonamidas/uso terapêutico , Síndrome da Veia Cava Superior/etiologia , Idoso , Antineoplásicos/administração & dosagem , Antineoplásicos/efeitos adversos , Esquema de Medicação , Humanos , Indóis/administração & dosagem , Indóis/efeitos adversos , Metástase Linfática , Masculino , Melanoma/genética , Terapia de Alvo Molecular/métodos , Proteínas Proto-Oncogênicas B-raf/genética , Neoplasias Cutâneas/genética , Sulfonamidas/administração & dosagem , Sulfonamidas/efeitos adversos , Síndrome da Veia Cava Superior/tratamento farmacológico , Síndrome da Veia Cava Superior/metabolismo , Tomografia Computadorizada por Raios X , Resultado do Tratamento , VemurafenibAssuntos
Carcinoma de Células Pequenas/diagnóstico , Fluordesoxiglucose F18/metabolismo , Neoplasias Pulmonares/diagnóstico , Tomografia por Emissão de Pósitrons , Síndrome da Veia Cava Superior/diagnóstico , Síndrome da Veia Cava Superior/metabolismo , Adulto , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Biópsia por Agulha Fina , Broncoscopia , Quimiorradioterapia , Transplante de Coração , Humanos , Masculino , Tomografia por Emissão de Pósitrons/métodos , Compostos Radiofarmacêuticos/metabolismo , Fumar , Síndrome da Veia Cava Superior/diagnóstico por imagem , Tomografia Computadorizada por Raios X , Resultado do TratamentoRESUMO
OBJECTIVE: To study clinical and histopathological features, and diagnosis of mediastinal tumours of haematopoietic and lymphoid tissues (MTHL). METHODS: Forty cases of MTHL were analyzed for clinicopathology by microscopy and immunohistochemical staining and in situ hybridization, according to the updated 2008 WHO classification of tumours of haematopoietic and lymphoid tissues. RESULTS: In 40 cases of MTHL, there were 20 males and 20 females. The ratio of male/female was 1:1. The mean age was 31.8 years and median age was 29 years (range, 12 - 70 years).Superior vena cava syndrome was observed in 28 cases. The specimens of 4 cases were obtained by lumpectomy, whereas 36 cases by biopsy (25 cases by thoracoscopy, 1 by core needle aspiration). Twenty cases lay in anterior mediastinum, and 2 in posterior, 1 in superior, 8 in anterior and superior, 2 in posterior and superior, 2 in anterior and middle, 1 in middle and anterior mediastinum.Frozen section were performed in 28 cases, and 17 cases were diagnosed as tumours of haematopoietic and lymphoid tissues (consistency ratio was 60.7%). Twelve cases were classical Hodgkin lymphomas (cHL) (8 were nodular sclerosis subtype, and 3 were mixed cellarity, 1 was lymphocyte-rich subtype), and 10 were primary mediastinal (thymic) large B cell lymphoma (PMBCL), 10 were precursor lymphocyte neoplasm [8 were T lymphoblastic leukemia/lymphomas (T-LBL), 2 were B-LBL], 1 was MALT lymphoma, 1 was composite lymphoma (PMBCL and cHL), 2 were myeloid sarcomas, 4 were gray zone lymphomas (GZL) (3 had morphology reminiscent of cHL, and 1 of DLBCL, all cases were positive for CD20, PAX5, CD30 and CD15).EBER were detected in 11 cases by in situ hybridization, 2 of which were positive (18.2%), and the 2 positive cases were cHL. CONCLUSIONS: MTHLs occur predominantly in adolescents and young adults, mainly present as superior vena cava syndrome and anterior mediasinal masses. cHL, PMBCL, T-LBL were the most common MTHLs.GZLs mainly occur in young adults, those whose morphology reminiscent of cHL, immunohistochemistry reminiscent of PMBCL, and vice versa. Thoracoscopy, frozen section and a suitable panel of antibodies were practical approaches to MTHL.
Assuntos
Doença de Hodgkin/patologia , Linfoma de Células B/patologia , Neoplasias do Mediastino/patologia , Leucemia-Linfoma Linfoblástico de Células Precursoras B/patologia , Leucemia-Linfoma Linfoblástico de Células T Precursoras/patologia , Adolescente , Adulto , Idoso , Antígenos CD20/metabolismo , Criança , Feminino , Seguimentos , Doença de Hodgkin/metabolismo , Humanos , Antígeno Ki-1/metabolismo , Antígenos CD15/metabolismo , Linfoma de Células B/metabolismo , Linfoma de Zona Marginal Tipo Células B/metabolismo , Linfoma de Zona Marginal Tipo Células B/patologia , Masculino , Neoplasias do Mediastino/metabolismo , Pessoa de Meia-Idade , Fator de Transcrição PAX5/metabolismo , Leucemia-Linfoma Linfoblástico de Células Precursoras B/metabolismo , Leucemia-Linfoma Linfoblástico de Células T Precursoras/metabolismo , Estudos Retrospectivos , Síndrome da Veia Cava Superior/metabolismo , Síndrome da Veia Cava Superior/patologia , Taxa de Sobrevida , Adulto JovemAssuntos
Pulmão/diagnóstico por imagem , Síndrome da Veia Cava Superior/diagnóstico por imagem , Veia Cava Superior/diagnóstico por imagem , Idoso , Dor no Peito/diagnóstico , Dor no Peito/etiologia , Dor no Peito/metabolismo , Diagnóstico Diferencial , Dispneia/diagnóstico , Dispneia/etiologia , Dispneia/metabolismo , Feminino , Humanos , Pulmão/metabolismo , Embolia Pulmonar/diagnóstico por imagem , Embolia Pulmonar/metabolismo , Cintilografia , Síndrome da Veia Cava Superior/complicações , Síndrome da Veia Cava Superior/metabolismo , Veia Cava Superior/metabolismoRESUMO
An unusual phenomenon during lung scintigraphy is presented. Besides visualization of the lungs, accumulation of Tc-99m macroaggregated albumin (MAA) was seen in a small part of the liver and in and around several thoracic vertebrae. Contrast-enhanced radiographic computed tomography revealed extensive collateral pathways, which were caused by a partially obstructed superior vena cava. Shunting of systemic venous blood flow through chest wall veins to the portal system was responsible for accumulation of MAA in the liver. Retrograde blood flow through dilated thoracic vertebral veins resulted in visualization of the bone marrow.
Assuntos
Fígado/diagnóstico por imagem , Fígado/metabolismo , Síndrome da Veia Cava Superior/diagnóstico por imagem , Síndrome da Veia Cava Superior/metabolismo , Agregado de Albumina Marcado com Tecnécio Tc 99m/farmacocinética , Vértebras Torácicas/diagnóstico por imagem , Vértebras Torácicas/metabolismo , Diagnóstico Diferencial , Feminino , Humanos , Achados Incidentais , Pessoa de Meia-Idade , Embolia Pulmonar/diagnóstico por imagem , Embolia Pulmonar/metabolismo , Cintilografia , Compostos Radiofarmacêuticos/farmacocinéticaRESUMO
Focal increased enhancement or radiopharmaceutical uptake in the liver has been associated with superior vena cava syndrome. This report describes the finding in a patient imaged with a relatively new agent, Tc-99m Apcitide. The collateral pathways responsible for the liver "hot spot" are reviewed, as is the role of Tc-99m Apcitide in deep venous thrombosis imaging.
Assuntos
Fígado/diagnóstico por imagem , Compostos de Organotecnécio/farmacocinética , Peptídeos Cíclicos , Compostos Radiofarmacêuticos/farmacocinética , Síndrome da Veia Cava Superior/diagnóstico por imagem , Neoplasias da Mama/complicações , Neoplasias da Mama/patologia , Feminino , Humanos , Fígado/metabolismo , Pessoa de Meia-Idade , Síndrome da Veia Cava Superior/etiologia , Síndrome da Veia Cava Superior/metabolismo , Tomografia Computadorizada de Emissão de Fóton ÚnicoRESUMO
BACKGROUND: Angiotropic large cell lymphoma (ALCL) is characterized by the intravascular proliferation of malignant lymphoid cells in small and medium-sized blood vessels. In the current study, the authors report an unusual case in which the initial presentation of the ALCL was that of superior vena cava (SVC) syndrome. METHODS: The case is presented, followed by a general review of the literature regarding ALCL. RESULTS: Surgical intervention was required for diagnosis in this case. Successful treatment with chemotherapy followed by involved field radiation ensued with a maintained disease remission at 48 months of follow-up. CONCLUSIONS: Although usually presenting in small blood vessels, ALCL can present initially with large blood vessel involvement and should be considered in the differential diagnosis of this condition, even in the absence of extravascular lymph node involvement. Aggressive treatment with antineoplastic therapy is warranted and may result in long term recurrence free survival.
Assuntos
Linfoma Difuso de Grandes Células B/patologia , Síndrome da Veia Cava Superior/patologia , Neoplasias Vasculares/patologia , Adulto , Antígenos CD20/análise , Diagnóstico Diferencial , Feminino , Humanos , Imuno-Histoquímica , Antígenos Comuns de Leucócito/análise , Linfoma Difuso de Grandes Células B/complicações , Linfoma Difuso de Grandes Células B/metabolismo , Síndrome da Veia Cava Superior/etiologia , Síndrome da Veia Cava Superior/metabolismo , Neoplasias Vasculares/complicações , Neoplasias Vasculares/metabolismoRESUMO
To investigate systemic oxygen (O2) transport, we calculated the oxygen delivery index (Do2I), oxygen consumption index (Vo2I) and oxygen extraction ratio (ER) in dogs with heartworm (HW) disease. The Do2I was 770 +/- 331 ml/min/kg in dogs mildly affected with pulmonary HW disease showing respiratory signs, mild anemia and mild cardiac insufficiency (n = 34); 238 +/- 155 ml/min/kg in dogs with ascitic pulmonary HW disease (n = 7); and 577 +/- 320 ml/min/kg in dogs with caval syndrome (CS) which survived (n = 15) or died (n = 7) after surgical HW removal. The Do2I was lower (P < 0.01) in all HW-infected groups, especially in ascites and CS-non-surviving dogs, than in HW-free dogs (n = 11, 1041 +/- 264 ml/min/kg). The Vo2I was higher in some mildly affected dogs (161 +/- 88 ml/min/kg), and lower (P < 0.01) in ascitic dogs (45 +/- 53 ml/min/kg) than in HW-free dogs (123 +/- 44 ml/min/kg). The ER was higher (P < 0.01) in all HW-infected groups than in HW-free dogs. The Do2I correlated significantly with Vo2I (r = 0.84, P < 0.01), and the Vo2I correlated significantly with ER (r = 0.48, P < 0.01). The Do2I correlated significantly with arterial O2 tension (r = 0.33), serum LDH (r = -0.46) and CK (r = -0.46) activities, serum urea nitrogen (UN, r = -0.32) and lactic acid (LA, r = -0.39) concentrations and cardiac index (r = 0.64).(ABSTRACT TRUNCATED AT 250 WORDS)